Docebenone, A-61589, AA-861-药物合成数据库

【药物名称】Docebenone, A-61589, AA-861

化学结构式(Chemical Structure):

参考文献No.	46487
标题:	Quinone compounds and their use in suppressing the production of SRS-A in mammals
作者:	Terao, S.; Shiraishi, M.; Maki, Y. (Takeda Chemical Industries, Ltd.)
来源:	EP 0038160; GB 2074158; JP 81145280; JP 81154433; JP 82109739

合成路线图解说明: The condensation of 2,5,6-trimethyl-3-(4-iodobutyl)hydroquinone (I) with octa-2,7-diyn-1-ol tetrahydropyranyl ether (II) by means of sodium amide in liquid ammonia gives 2,5,6-trimethyl-3-[12-(tetrahydropyranyloxy)-5,10-dodecadiynyl]hydroquinone (III), which is oxidized with ceric ammonium nitrate in aqueous acetonitrile and deprotected in the usual way.

参考文献No.	61942
标题:	AA-861
作者:	Hillier, K.; Casta馿r, J.; Serradell, M.N.
来源:	Drugs Fut 1984,9(10),725

合成路线图解说明: The condensation of 2,5,6-trimethyl-3-(4-iodobutyl)hydroquinone (I) with octa-2,7-diyn-1-ol tetrahydropyranyl ether (II) by means of sodium amide in liquid ammonia gives 2,5,6-trimethyl-3-[12-(tetrahydropyranyloxy)-5,10-dodecadiynyl]hydroquinone (III), which is oxidized with ceric ammonium nitrate in aqueous acetonitrile and deprotected in the usual way.