【药物名称】Azolastone, Mitozolomide, CCRG-81080, NSC-353451, M&B-39565, 46241-RP
化学结构式(Chemical Structure):
参考文献No.2177
标题:Tetrazine derivs., process for their preparation and pharmaceutical compsns. containing them
作者:Lunt, E.; Stevens, M.F.G.; Stone, R.; Woolbridge, K.R.H. (Cancer Research Campaign Technology Ltd.)
来源:BE 894175; DE 3231255; FR 2511679; GB 2104522; JP 1983043975; US 5260291
合成路线图解说明:

By cyclization of 5-diazoimidazole-4-carboxamide (I) with 2-chloroethyl isocyanate (II) in dichloromethane.

合成路线图解说明:

By reaction of 5-diazoimidazole-4-carboxamide (II), prepared by diazotization of 5-aminoimidazole-4-carboxamide (I) with nitrous acid, with methylisocyanate (III) either alone or in dichloromethane.

参考文献No.75318
标题:Mitozolomide
作者:Hopkins, S.J.; Serradell, M.N.; Casta馿r, J.
来源:Drugs Fut 1984,9(11),827
合成路线图解说明:

By cyclization of 5-diazoimidazole-4-carboxamide (I) with 2-chloroethyl isocyanate (II) in dichloromethane.

参考文献No.265060
标题:Antitumor imidazotetrazinones. 1. Synthesis and chemistry of 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one, a novel broad-spectrum antitumor agent
作者:Stone, R.; Newton, C.G.; Gibson, N.W.; Baig, G.U.; Lunt, E.; Stevens, M.F.G.; Hickman, J.A.
来源:J Med Chem 1984,27(196-201),196
合成路线图解说明:

By cyclization of 5-diazoimidazole-4-carboxamide (I) with 2-chloroethyl isocyanate (II) in dichloromethane.

合成路线图解说明:

By reaction of 5-diazoimidazole-4-carboxamide (II), prepared by diazotization of 5-aminoimidazole-4-carboxamide (I) with nitrous acid, with methylisocyanate (III) either alone or in dichloromethane.

参考文献No.604646
标题:The role of isocyanates in the toxicity of antitumor haloalkylnitrosoureas
作者:Gibson, N.W.; Hickman, J.A.
来源:Biochem Pharmacol 1982,31(17),2795-2800
合成路线图解说明:

By cyclization of 5-diazoimidazole-4-carboxamide (I) with 2-chloroethyl isocyanate (II) in dichloromethane.

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