Acitemate, Chinoin-123-药物合成数据库

【药物名称】Acitemate, Chinoin-123

化学结构式(Chemical Structure):

参考文献No.	75302
标题:	CHINOIN-123
作者:	Paton, D.M.; Casta馿r, J.
来源:	Drugs Fut 1979,4(11),788

合成路线图解说明: The reaction of 3-ethoxycarbonyl-6-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido [1,2-a]pyrimidine (I) with glyoxilic acid (II) in ethanolic HCl gives 3-ethoxycarbonyl-6-methyl-4-oxo-9-carboxymethylen-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine (IIIa-b), which is reduced with H2 over Pd/C in ethanol.

参考文献No.	701472
标题:
作者:	Hermecz, I.; et al.
来源:	US 4123533

合成路线图解说明: The reaction of 3-ethoxycarbonyl-6-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido [1,2-a]pyrimidine (I) with glyoxilic acid (II) in ethanolic HCl gives 3-ethoxycarbonyl-6-methyl-4-oxo-9-carboxymethylen-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine (IIIa-b), which is reduced with H2 over Pd/C in ethanol.