Lenampicillin hydrochloride, KBT-1585, KB-1585, Takacillin, Veracillin-药物合成数据库

【药物名称】Lenampicillin hydrochloride, KBT-1585, KB-1585, Takacillin, Veracillin

化学结构式(Chemical Structure):

参考文献No.	46500
标题:	Novel ampicillin esters and production thereof
作者:	Sakamoto, F.; Ikeda, S.; Tsukamoto, G.; Utsumi, I. (Kanebo Pharmaceuticals, Ltd.)
来源:	EP 0039086; EP 0039477; EP 0061206; US 4389408

合成路线图解说明: The bromination of 4,5-dimethyl-1,3-dioxolen-2-one (I) with N-bromo-succinimide (NBS) and azobisisobutyronitrile (AIBN) in CCl4 gives 4-methyl-5-bromomethyl-1,3-diioxolen-2-one (II), which is then condensed with ampicillin (III) by means of KHCO3 and benzaldehyde in DMF.

参考文献No.	74968
标题:	KB-1585
作者:	Serradell, M.N.; Casta馿r, J.; Blancafort, P.
来源:	Drugs Fut 1983,8(11),920

合成路线图解说明: The bromination of 4,5-dimethyl-1,3-dioxolen-2-one (I) with N-bromo-succinimide (NBS) and azobisisobutyronitrile (AIBN) in CCl4 gives 4-methyl-5-bromomethyl-1,3-diioxolen-2-one (II), which is then condensed with ampicillin (III) by means of KHCO3 and benzaldehyde in DMF.