Ponalrestat, MK-538, ICI-128436, Prodiax, Statil-药物合成数据库

【药物名称】Ponalrestat, MK-538, ICI-128436, Prodiax, Statil

化学结构式(Chemical Structure):

参考文献No.	39871
标题:	Increasing vigilance or treating cerebral insuffi
作者:	Pf鋐fli, P. (Novartis AG)
来源:	GB 1492579; US 4146643

合成路线图解说明: The condensation of ethyl 3,4-dihydro-4-oxo-phthalazine-1-acetate (I) with 4-bromo-2-fluoro benzyl bromide (II) by means of NaH in hot DMF gives ethyl 3-(4-bromo-2-fluorobenzyl)-3,4-dihydro-4-oxophthalazine-1-acetate (III), which is saponified with KOH in refluxing ethanol.

参考文献No.	64824
标题:	ICI-128436
作者:	Casta馿r, J.; Prous, J.
来源:	Drugs Fut 1987,12(4),347

合成路线图解说明: The condensation of ethyl 3,4-dihydro-4-oxo-phthalazine-1-acetate (I) with 4-bromo-2-fluoro benzyl bromide (II) by means of NaH in hot DMF gives ethyl 3-(4-bromo-2-fluorobenzyl)-3,4-dihydro-4-oxophthalazine-1-acetate (III), which is saponified with KOH in refluxing ethanol.