PK-9084-药物合成数据库

【药物名称】PK-9084

化学结构式(Chemical Structure):

参考文献No.	47468
标题:	1-(4 Quinolyl) 2- or 3- (2- or 3- piperidyl or pyrrolidinyl) ethanone or propanone, process for their preparation and their use as medicaments
作者:	Dubroeucq, M.C.; Gueremy, C.G.A.; Lefur, G.R.; Mizoule, J. (Pharmindustrie)
来源:	EP 0042781

合成路线图解说明: The reaction of ethyl 2-phenylquinoline-4-carboxylate (I) with N-benzoylpipepidine-3-acetic acid ethyl ester (II) by means of potassium hydride in THF gives 2-phenyl-4-[2-(3-piperidyl)acetyl]quinoline (III), which is reduced with hydrazine in dietyleneglycol at 180 C.

参考文献No.	71695
标题:	PK-8165 and PK-9084
作者:	Blancafort, P.; McGillion, F.B.; Casta馿r, J.; Serradell, M.N.
来源:	Drugs Fut 1982,7(9),648

合成路线图解说明: The reaction of ethyl 2-phenylquinoline-4-carboxylate (I) with ethyl N-benzoylpiperidyl-4-acetate (II) by means of potassium tert-butylate in THF gives 2-phenyl-4-(4-piperidylacetyl)quinone (III), which is then reduced with hydrazine at 180 C.

合成路线图解说明: The reaction of ethyl 2-phenylquinoline-4-carboxylate (I) with N-benzoylpipepidine-3-acetic acid ethyl ester (II) by means of potassium hydride in THF gives 2-phenyl-4-[2-(3-piperidyl)acetyl]quinoline (III), which is reduced with hydrazine in dietyleneglycol at 180 C.