Cloricromene, AD-6, Proendotel-药物合成数据库

【药物名称】Cloricromene, AD-6, Proendotel

化学结构式(Chemical Structure):

参考文献No.	61946
标题:	AD-6
作者:	Casta馿r, J.; Hillier, K.; Serradell, M.N.; Blancafort, P.
来源:	Drugs Fut 1979,4(10),701

合成路线图解说明: The cyclization of 2-chlororesorcine (I) with ethyl alpha-(beta-diethylaminoethyl) acetoacetate (II) by means of p-toluenesulfonic acid and polyphosphoric acid gives 8-chloro-3-(beta-diethylaminoethyl)-4-methyl-7-hydroxycoumarin (III), which is then condensed with ethyl chloroacetate (IV) by means of K2CO3 in refluxing acetone.

参考文献No.	700994
标题:	Selected process for producing monohalogenated derivatives of 7-hydroxy-coumarin
作者:	Della Valle, F.
来源:	BE 0871315; DE 2846083; ES 474445; FR 2412541; FR 2412542; GB 2008109; JP 54079282; US 4296039

合成路线图解说明: The cyclization of 2-chlororesorcine (I) with ethyl alpha-(beta-diethylaminoethyl) acetoacetate (II) by means of p-toluenesulfonic acid and polyphosphoric acid gives 8-chloro-3-(beta-diethylaminoethyl)-4-methyl-7-hydroxycoumarin (III), which is then condensed with ethyl chloroacetate (IV) by means of K2CO3 in refluxing acetone.