Sch-28080-药物合成数据库

【药物名称】Sch-28080

化学结构式(Chemical Structure):

参考文献No.	61920
标题:	SCH-28,080
作者:	Hillier, K.; Serradell, M.N.; Casta馿r, J.; Blancafort, P.
来源:	Drugs Fut 1982,7(10),755

合成路线图解说明: By cyclization of 2-amino-3-benzyloxypyridine (I) with 3-chloro-4-oxopentanonitrile (II) by means of thiethylamine in ethanol. Compound (I) is prepared by benzylation of 2-amino-3-hydroxypyridine (III) with benzyl chloride (IV) by means of NaOH in water-CH2Cl2. Compound (II) is prepared by chlorination of 4-oxopentanonitrile (V) with SO2Cl2 in ether.

参考文献No.	701339
标题:
作者:	Puchalski, C.; Bristol, J.A.
来源:	EP 0033094

合成路线图解说明: By cyclization of 2-amino-3-benzyloxypyridine (I) with 3-chloro-4-oxopentanonitrile (II) by means of thiethylamine in ethanol. Compound (I) is prepared by benzylation of 2-amino-3-hydroxypyridine (III) with benzyl chloride (IV) by means of NaOH in water-CH2Cl2. Compound (II) is prepared by chlorination of 4-oxopentanonitrile (V) with SO2Cl2 in ether.