Moxonidine hydrochloride hydrate, LY-326869, BE-5895, BDF-5895, Norcynt, Nucynt, Moxon, Normoxin, Physiotens, Lomox, Cynt-药物合成数据库

【药物名称】Moxonidine hydrochloride hydrate, LY-326869, BE-5895, BDF-5895, Norcynt, Nucynt, Moxon, Normoxin, Physiotens, Lomox, Cynt

化学结构式(Chemical Structure):

参考文献No.	40321
标题:	Novel remedy for peptic ulcer
作者:	Mutsumi, M. (Nippon Chemiphar Co., Ltd.)
来源:	JP 1982075920

合成路线图解说明: The condensation of 5-amino 2 methyl 4,6-dichloropyrimidine (I) with 1-acetyl-2-imidazolin-2-one (II) by means of POCl3 at 50 C gives 4,6-dichloro-2-methyl-5-(1-acetyl-2-imidazolin-2-ylamino)pyrimidine (III), which is then methoxylated and desacetylated by treatment with sodium methoxide in refluxing methanol.

参考文献No.	67217
标题:	Moxonidine hydrochloride
作者:	Mannhold, R.
来源:	Drugs Fut 1987,12(6),553

合成路线图解说明: The condensation of 5-amino 2 methyl 4,6-dichloropyrimidine (I) with 1-acetyl-2-imidazolin-2-one (II) by means of POCl3 at 50 C gives 4,6-dichloro-2-methyl-5-(1-acetyl-2-imidazolin-2-ylamino)pyrimidine (III), which is then methoxylated and desacetylated by treatment with sodium methoxide in refluxing methanol.