Fentiapril, Rentiapril, DE-040, SA-446-药物合成数据库

【药物名称】Fentiapril, Rentiapril, DE-040, SA-446

化学结构式(Chemical Structure):

参考文献No.	62037
标题:	SA-446
作者:	Sneddon, J.M.; Casta馿r, J.; Blancafort, P.; Serradell, M.N.
来源:	Drugs Fut 1983,8(1),36

合成路线图解说明: The condensation of 2-(2-hydroxyphenyl)-4-thiazolidinecarboxylic acid (I) with S-benzoyl-3-mercaptopropanoyl chloride (II) by means of triethylamine in acetone gives 3-(S-benzoyl-3-mercaptopropanoyl)-2-(2-hydroxyphenyl)-4-thiazolidinecarboxylic acid (III), which is debenzylated by a treatment with NH3.

参考文献No.	701214
标题:
作者:
来源:	BE 0875365

合成路线图解说明: The condensation of 2-(2-hydroxyphenyl)-4-thiazolidinecarboxylic acid (I) with S-benzoyl-3-mercaptopropanoyl chloride (II) by means of triethylamine in acetone gives 3-(S-benzoyl-3-mercaptopropanoyl)-2-(2-hydroxyphenyl)-4-thiazolidinecarboxylic acid (III), which is debenzylated by a treatment with NH3.