Tiamenidine, Hoe-42-440(HCl), Hoe-440, Symcor, Sundralen-药物合成数据库

【药物名称】Tiamenidine, Hoe-42-440(HCl), Hoe-440, Symcor, Sundralen

化学结构式(Chemical Structure):

参考文献No.	61879
标题:	Tiamenidine
作者:	Casta馿r, J.; Thorpe, P.
来源:	Drugs Fut 1976,1(10),502

合成路线图解说明: The reaction of N-(2-chloro-4-methyl-3-thienyl)thiourea (I) with methyl iodide in methanol gives S-methyl-N-(2-chloro-4-methyl-3-thienyl)isothiouronium iodide (II), m.p. 113-5 C, which is then condensed with ethylenediamine (A) in methanol at 100 C.

参考文献No.	701136
标题:	2-(Thienyl-3'-amino)1,3-diazacycloalkenes
作者:	Rippel, R.; et al.
来源:	DE 1941761; FR 2068493; FR 2068505; GB 1312133; US 3758476

合成路线图解说明: The reaction of N-(2-chloro-4-methyl-3-thienyl)thiourea (I) with methyl iodide in methanol gives S-methyl-N-(2-chloro-4-methyl-3-thienyl)isothiouronium iodide (II), m.p. 113-5 C, which is then condensed with ethylenediamine (A) in methanol at 100 C.