Bisantrene hydrochloride, NSC-337766, ADD, CL-216942, Cyabin, Zantrene-药物合成数据库

【药物名称】Bisantrene hydrochloride, NSC-337766, ADD, CL-216942, Cyabin, Zantrene

化学结构式(Chemical Structure):

参考文献No.	75183
标题:	CL-216,942
作者:	Hillier, K.; Blancafort, P.; Serradell, M.N.; Casta馿r, J.
来源:	Drugs Fut 1981,6(12),762

合成路线图解说明: The reaction of anthracene (I) with refluxing vinylene carbonate (II) gives 9,10-dihydro-9,10-ethanoanthracene-11,12-diol cyclic carbonate (III), which is hydrolyzed with KOH in hot ethanol water affording 9,10-dihydro-9,10-ethanoanthracene-11,12-diol (IV). The oxidation of (IV) with lead tetraacetate in acetic acid yields 9,10-anthracenedicarboxaldehyde (V), which is finally condensed with 2-hydrazino-2-imidazoline (VI) by means of HCl in refluxing ethanol.

参考文献No.	700874
标题:	Novel dihydrobenzanthracene derivatives
作者:	Murdock, K.C.; Durr, F.E.; Child, R.G.; Lang, S.A.Jr.; Lee, V.J.; Lin, Y.-I.
来源:	DE 2850822; US 4187373; US 4235996

合成路线图解说明: The reaction of anthracene (I) with refluxing vinylene carbonate (II) gives 9,10-dihydro-9,10-ethanoanthracene-11,12-diol cyclic carbonate (III), which is hydrolyzed with KOH in hot ethanol water affording 9,10-dihydro-9,10-ethanoanthracene-11,12-diol (IV). The oxidation of (IV) with lead tetraacetate in acetic acid yields 9,10-anthracenedicarboxaldehyde (V), which is finally condensed with 2-hydrazino-2-imidazoline (VI) by means of HCl in refluxing ethanol.