Tilisolol hydrochloride, N-696, Daim, Selecal-药物合成数据库

【药物名称】Tilisolol hydrochloride, N-696, Daim, Selecal

化学结构式(Chemical Structure):

参考文献No.	46774
标题:	Isocarbostyril derivatives
作者:	Fukushima, H.; Suzuki, Y. (Nisshin Flour Milling Co., Ltd.)
来源:	DE 2631080; GB 1501149; JP 52012178

合成路线图解说明: The condensation of N-methyl-4-hydroxyisocarbostyril (I) with epichlorohydrin (II) by means of sodium methoxide in hot methanol gives 4-(2,3-epoxypropoxy)-N-methylisocarbostyril (III), which is then treated with tert-butylamine (IV) in methanol, and with HCl.

参考文献No.	75158
标题:	N-696
作者:	Serradell, M.N.; Blancafort, P.; Thorpe, P.J.; Casta馿r, J.
来源:	Drugs Fut 1982,7(12),889

合成路线图解说明: The condensation of N-methyl-4-hydroxyisocarbostyril (I) with epichlorohydrin (II) by means of sodium methoxide in hot methanol gives 4-(2,3-epoxypropoxy)-N-methylisocarbostyril (III), which is then treated with tert-butylamine (IV) in methanol, and with HCl.