Lisinopril, ICI-209K, MK-521, Doneka, Prinzide, Zestril, Longes, Coric, Acerbon, Vivatec, Carace, Prinivil-药物合成数据库

【药物名称】Lisinopril, ICI-209K, MK-521, Doneka, Prinzide, Zestril, Longes, Coric, Acerbon, Vivatec, Carace, Prinivil

化学结构式(Chemical Structure):

参考文献No.	40769
标题:	Carboxyalkyl dipeptide derivs., process for preparing them and pharmaceutical compsn. containing them
作者:	Wyvratt, M.J.; Harris, E.E.; Patchett, A.A.; Tristram, E.W. (Merck & Co., Inc.)
来源:	EP 0012401

合成路线图解说明: by reductocondensation of 4-phenyl-2-oxo butyric acid (IX) with L-alanyl-L-proline (IV) by means of sodium cyanoborohydride and NaOH in water.

合成路线图解说明: The reductocondensation of N(epsilon)-tert-butoxycarbonyl-lysyl proline (I) with 2-oxobutyric acid (II) by means of sodium cyanoborohydride in water gives the protected compound (III), which is finally treated with HCl in ethyl acetate.

参考文献No.	49587
标题:	MK-521
作者:	Blancafort, P.; Casta馿r, J.; Sneddon, J.M.; Serradell, M.N.
来源:	Drugs Fut 1983,8(11),925

合成路线图解说明: The reductocondensation of N(epsilon)-tert-butoxycarbonyl-lysyl proline (I) with 2-oxobutyric acid (II) by means of sodium cyanoborohydride in water gives the protected compound (III), which is finally treated with HCl in ethyl acetate.