Doxazosin mesylate, UK-33274, Dedralen, Carduran Neo, Zoxan, Progandol, Tensiobas, Cardenalin, Cardular, Cardura, Carduran-药物合成数据库

【药物名称】Doxazosin mesylate, UK-33274, Dedralen, Carduran Neo, Zoxan, Progandol, Tensiobas, Cardenalin, Cardular, Cardura, Carduran

化学结构式(Chemical Structure):

参考文献No.	44056
标题:	Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines
作者:	Campbell, S.F. (Pfizer Inc.)
来源:	DE 2847623; FR 24079529; US 4188390

合成路线图解说明: The acylation of piperazine (I) with 1,4-benzodioxan-2-ylcarbonyl chloride (II) by means of sodium acetate in water-acetone gives N-(1,4-benzodioxan-2-carbonyl)piperazine (III), which is then condensed with 4-amino-2-chloro-6,7-dimethoxyquinazoline (IV) in refluxing butanol.

参考文献No.	49589
标题:	Doxazosin
作者:	Serradell, M.N.; Casta馿r, J.; Blancafort, P.
来源:	Drugs Fut 1982,7(12),877

合成路线图解说明: The acylation of piperazine (I) with 1,4-benzodioxan-2-ylcarbonyl chloride (II) by means of sodium acetate in water-acetone gives N-(1,4-benzodioxan-2-carbonyl)piperazine (III), which is then condensed with 4-amino-2-chloro-6,7-dimethoxyquinazoline (IV) in refluxing butanol.