Zaltoprofen, ZC-102, CN-100, Peon, Soleton-药物合成数据库

【药物名称】Zaltoprofen, ZC-102, CN-100, Peon, Soleton

化学结构式(Chemical Structure):

参考文献No.	9812
标题:	Dibenzothiepine derivs., process for their prepara
作者:	Fujimoto, Y.; Yamabe, S. (Nippon Chemiphar Co., Ltd.)
来源:	DE 2941869; US 4247706

合成路线图解说明: The cyclization of 5-(1-cyanoethyl)-2-(phenylthio)phenylacetic acid (I) with polyphosphoric acid at 120 C gives 2-(10-oxo-10,11-dihydrodibenzo[b,flthiepin-2-yl)propionitrile (II), which is then hydrolyzed with KOH in refluxing ethanol-water.

参考文献No.	62387
标题:	CN-100
作者:	Prous, J.; Casta馿r, J.
来源:	Drugs Fut 1988,13(4),302

合成路线图解说明: The cyclization of 5-(1-cyanoethyl)-2-(phenylthio)phenylacetic acid (I) with polyphosphoric acid at 120 C gives 2-(10-oxo-10,11-dihydrodibenzo[b,flthiepin-2-yl)propionitrile (II), which is then hydrolyzed with KOH in refluxing ethanol-water.