Eclazolast, RHC-2871, REV-2871, CHBZ-药物合成数据库

【药物名称】Eclazolast, RHC-2871, REV-2871, CHBZ

化学结构式(Chemical Structure):

参考文献No.	9814
标题:	Esters of benzoxa(thia)zole-2-carboxylic acids
作者:	Brown, R.E.; St. Georgiev, V.; Loev, B. (USV Pharmaceutical Corp.)
来源:	US 4298742

合成路线图解说明: The reaction of 6-chloro-1,4-benzoxazine-2,3-dione (I) with SOCl2 and DMF in refluxing toluene gives 3,6-dichloro-1,4-benzoxazin-2-one (II), which is then treated with 2-ethoxyethanol (III) and Na2CO3 at 70 C.

参考文献No.	62988
标题:	Eclazolast
作者:	Chu, S.S.
来源:	Drugs Fut 1988,13(5),406

合成路线图解说明: The reaction of 6-chloro-1,4-benzoxazine-2,3-dione (I) with SOCl2 and DMF in refluxing toluene gives 3,6-dichloro-1,4-benzoxazin-2-one (II), which is then treated with 2-ethoxyethanol (III) and Na2CO3 at 70 C.