Bretazenil, Ro-16-6028/000, Ro-16-6028-药物合成数据库

【药物名称】Bretazenil, Ro-16-6028/000, Ro-16-6028

化学结构式(Chemical Structure):

参考文献No.	9815
标题:	Imidazodiazepines, process for their preparation a
作者:	Hunkeler, W.; Kyburz, E. (F. Hoffmann-La Roche AG)
来源:	EP 0059391; US 4353827

合成路线图解说明: 5-Bromo-2H-3,1-benzoxazine-2,4(1H)-dione (I) and L-proline (II) are heated in DMF to form (S)-6-bromo-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H)-dione (III). This lactam is then reacted with t-BuOK and diphenyl chlorophosphate, and subsequently with the anion of tert-butyl isocyanoacetate.

参考文献No.	63039
标题:	Ro 16-6028
作者:	Roncari, G.; Jauch, R.; Timm, U.; Pieri, L.; Merz, W.A.; Hunkeler, W.
来源:	Drugs Fut 1988,13(8),730

合成路线图解说明: 5-Bromo-2H-3,1-benzoxazine-2,4(1H)-dione (I) and L-proline (II) are heated in DMF to form (S)-6-bromo-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H)-dione (III). This lactam is then reacted with t-BuOK and diphenyl chlorophosphate, and subsequently with the anion of tert-butyl isocyanoacetate.