SK&F-100330A-药物合成数据库

【药物名称】SK&F-100330A

化学结构式(Chemical Structure):

参考文献No.	62063
标题:	SK&F-100330-A
作者:	L鰏cher, W.
来源:	Drugs Fut 1986,11(1),39

合成路线图解说明: The methyl ester of 1,2,5,6-tetrahydro-3-pyridinecarboxylate (guvacine) (II) is N-alkylated with 4,4-diphenyl-3-butenyl bromide (I). The methyl ester of N-(4,4-diphenyl-3-butenyl)guvacine thus obtained is then hydrolvzed with HCl to yield the hydrochloride of the free acid.

参考文献No.	555577
标题:	Orally active and potent inhibitors of gamma-aminobutyric acid uptake
作者:	Fe, A.; Bondinell, W.E.; Dandridge, P.A.; Frazee, J.S.; Garvey, E.; Girard, G.R.; Kaiser, C.; Ku, T.W.; Lafferty, J.J.; Moonsammy, G.I.; et al.
来源:	J Med Chem 1985,28(5),653

合成路线图解说明: The ethyl ester of 3-piperidinecarboxylic acid (nipecotic acid) (II) is N-alkylated with 4,4-diphenyl-3-butenyl bromide (I). The ethyl ester of N-(4,4-diphenyl-3-butenyl)nipecotic acid thus obtained is then hydrolyzed with HCl to yield the hydrochloride of the free acid.

合成路线图解说明: The methyl ester of 1,2,5,6-tetrahydro-3-pyridinecarboxylate (guvacine) (II) is N-alkylated with 4,4-diphenyl-3-butenyl bromide (I). The methyl ester of N-(4,4-diphenyl-3-butenyl)guvacine thus obtained is then hydrolvzed with HCl to yield the hydrochloride of the free acid.