【药物名称】Peplomycin, NK-631(sulfate), Pepleo
化学结构式(Chemical Structure):
参考文献No.64857
标题:Peplomycin
作者:Serradell, M.N.; Blancafort, P.; Thorpe, P.J.; Casta馿r, J.
来源:Drugs Fut 1981,6(2),101
合成路线图解说明:

By reaction of bleomycinic acid copper salt (I) with N-[(S)-1'-phenylethyl]-1,3-diaminopropane (II) by means of carbodiimides, or by means of 6-chloro-1-(p-chlorobenzenesulfonyloxy)benzotriazole in DMF.

参考文献No.700844
标题:Novel process for producing antibiotics bleomycin
作者:Umezawa, H.; et al.
来源:CA 923534; FR 2034552; GB 1292081; US 3846400
合成路线图解说明:

By reaction of bleomycinic acid copper salt (I) with N-[(S)-1'-phenylethyl]-1,3-diaminopropane (II) by means of carbodiimides, or by means of 6-chloro-1-(p-chlorobenzenesulfonyloxy)benzotriazole in DMF.

参考文献No.700845
标题:Preparation of 3-[(S)-1'-phenylethylamino]-propylamino-bleomycin
作者:Kunishima, A.; et al.
来源:JP 54041387
合成路线图解说明:

By reaction of bleomycinic acid copper salt (I) with N-[(S)-1'-phenylethyl]-1,3-diaminopropane (II) by means of carbodiimides, or by means of 6-chloro-1-(p-chlorobenzenesulfonyloxy)benzotriazole in DMF.

参考文献No.700846
标题:3-[(S)-1'-Phenylethylamino]propylaminobleomycin, non-toxic salt thereof, and method for producing same
作者:Takita, T.; et al.
来源:FR 2396021; GB 2001962; US 4195018; US 4238391
合成路线图解说明:

By reaction of bleomycinic acid copper salt (I) with N-[(S)-1'-phenylethyl]-1,3-diaminopropane (II) by means of carbodiimides, or by means of 6-chloro-1-(p-chlorobenzenesulfonyloxy)benzotriazole in DMF.

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