Vadocaine hydrochloride, K-242-HCl, ORK-242-HCl-药物合成数据库

【药物名称】Vadocaine hydrochloride, K-242-HCl, ORK-242-HCl

化学结构式(Chemical Structure):

参考文献No.	9818
标题:	Novel anilides, their process of preparation and t
作者:	Kaila, J.O.W.; Honkanen, E.J.; Alberty, J.E.; Hukki, J.J. (Orion Corporation)
来源:	BE 0873957; US 4353914

合成路线图解说明: The condensation of 3-chloropropionyl chloride (I) with 2,4 dimethyl-6 methoxyaniline (II) by means of sodium acetate in glacial acetic acid gives 3-chloro-N-(2,4-dimethyl-6-methoxyphenyl)propionamide (III), which is condensed with 2-methylpiperidine (IV) in refluxing anhydrous benzene.

参考文献No.	70083
标题:	Vadocaine hydrochloride
作者:	Prous, J.; Casta馿r, J.
来源:	Drugs Fut 1988,13(10),936

合成路线图解说明: The condensation of 3-chloropropionyl chloride (I) with 2,4 dimethyl-6 methoxyaniline (II) by means of sodium acetate in glacial acetic acid gives 3-chloro-N-(2,4-dimethyl-6-methoxyphenyl)propionamide (III), which is condensed with 2-methylpiperidine (IV) in refluxing anhydrous benzene.