Oltipraz, RP-35972-药物合成数据库

【药物名称】Oltipraz, RP-35972

化学结构式(Chemical Structure):

参考文献No.	68117
标题:	Oltipraz
作者:	Hillier, K.; Blancafort, P.; Serradell, M.N.; Casta馿r, J.
来源:	Drugs Fut 1980,5(7),359

合成路线图解说明: The methylation of ethyl 3-pyrazinyl-3-oxopropionate (I) with methyl iodide and K2CO3 in acetone gives ethyl 2-methyl-3-pyrazinyl-3-oxopropionate (II), which is then treated with P2S5 in refluxing toluene.

参考文献No.	700936
标题:	Nouveaux d閞iv閟 du dithiole-1,2, leur pr閜aration et les compositions qui les contiennent
作者:	Bareau, M.; et al.
来源:	BE 0851262; FR 2340730; JP 57081484; JP 57112391

合成路线图解说明: The methylation of ethyl 3-pyrazinyl-3-oxopropionate (I) with methyl iodide and K2CO3 in acetone gives ethyl 2-methyl-3-pyrazinyl-3-oxopropionate (II), which is then treated with P2S5 in refluxing toluene.