Pentopril, CGS-13945-药物合成数据库

【药物名称】Pentopril, CGS-13945

化学结构式(Chemical Structure):

参考文献No.	47446
标题:	1-Carboxyalkanoylindolin-2-carboxylic acids and derivs. thereof, processes for their preparation, and pharmaceutical compsns. containing these cpds. as well as their use
作者:	Gruenfeld, N. (Novartis AG)
来源:	EP 0050850

合成路线图解说明: The ethanolysis of 2,4-dimethylglutaric anhydride (I) gives the monoethyl ester of 2,4-dimethylglutaric acid (II), which by reaction with oxalyl chloride is converted into the monoacyl chloride (III). Finally, this compound is condensed with indoline-2-carboxylic acid (IV) hy means of K2CO3 in pyridine.

参考文献No.	75181
标题:	CGS-13945
作者:	Serradell, M.N.; Casta馿r, J.; Blancafort, P.
来源:	Drugs Fut 1983,8(12),1010

合成路线图解说明: The ethanolysis of 2,4-dimethylglutaric anhydride (I) gives the monoethyl ester of 2,4-dimethylglutaric acid (II), which by reaction with oxalyl chloride is converted into the monoacyl chloride (III). Finally, this compound is condensed with indoline-2-carboxylic acid (IV) hy means of K2CO3 in pyridine.