Spiroplatin, TNO-6, NSC-311056-药物合成数据库

【药物名称】Spiroplatin, TNO-6, NSC-311056

化学结构式(Chemical Structure):

参考文献No.	75196
标题:	Spiroplatin
作者:	Chang, P.
来源:	Drugs Fut 1984,9(12),907

合成路线图解说明: The reaction of 1,1-di(aminomethyl)cyclohexane (I) with potassium iodide and potassium tetrachloroplatinate in water gives cis-diiodo-1,1-di(aminomethyl)cyclohexane platinum (II), which is treated with Ag2SO4.

参考文献No.	701191
标题:	Platinum-diamine complexes, a method for the preparation of a medicine using such a platinum-diamine complex for the treatment of malignant tumor in mice
作者:	Berg, J.; Bulten, E.J.; Verbeek, F.
来源:	DE 2927056; FR 2430406; FR 2511685; GB 2024823; US 4410544

合成路线图解说明: The reaction of 1,1-di(aminomethyl)cyclohexane (I) with potassium iodide and potassium tetrachloroplatinate in water gives cis-diiodo-1,1-di(aminomethyl)cyclohexane platinum (II), which is treated with Ag2SO4.