Azacrown-TEPA-药物合成数据库

【药物名称】Azacrown-TEPA

化学结构式(Chemical Structure):

参考文献No.	74474
标题:	Azacrown-TEPA
作者:	Lukszo, J.; Sosnovsky, G.
来源:	Drugs Fut 1985,10(4),275

合成路线图解说明: Title compound can be prepared by two different ways: 1) The reaction of 1,4,7,10-tetraoxa-13-azacyclopentandecane (I) with phosphoryl chloride in the presence of triethylamine in diethyl ether gives 13-(dichlorophosphoryl)-1,4,7,10-tetraoxa-13-azacyclopentandecane (II), which is subsequently reacted with aziridine (III) in the presence of triethylamine to give azacrown-TEPA. 2) The reaction of the aziridine (III) with phosphoryl chloride in the presence of triethylamine in diethyl ether gives bis(1-aziridinyl)chlorophosphine oxide (IV), which is subsequently reacted with 1,4,7,10-tetraoxa-13-azacyclopentandecane (I) in the presence of triethylamine to afford azacrown-TEPA.

参考文献No.	800010
标题:	Facile synthesis of monoaza crown ethers
作者:	Okahara, M.; Nakatsuji, Y.; Maeda, H.
来源:	J Med Chem 1981,II471-472

合成路线图解说明: Title compound can be prepared by two different ways: 1) The reaction of 1,4,7,10-tetraoxa-13-azacyclopentandecane (I) with phosphoryl chloride in the presence of triethylamine in diethyl ether gives 13-(dichlorophosphoryl)-1,4,7,10-tetraoxa-13-azacyclopentandecane (II), which is subsequently reacted with aziridine (III) in the presence of triethylamine to give azacrown-TEPA. 2) The reaction of the aziridine (III) with phosphoryl chloride in the presence of triethylamine in diethyl ether gives bis(1-aziridinyl)chlorophosphine oxide (IV), which is subsequently reacted with 1,4,7,10-tetraoxa-13-azacyclopentandecane (I) in the presence of triethylamine to afford azacrown-TEPA.