【药物名称】Trifluoropentoxypicolinic acid, ND-186 H-5
化学结构式(Chemical Structure):
参考文献No.40773
标题:5-Alkoxypicolinic acid ester, its preparation, and hypotensive agent containing the same
作者:Hachisu, M.; Inouye, S.; Sezaki, M.; Shimomura, K.; Koeda, T.; Tsuruoka, T.; Niida, T.; Shibata, U.; Miyamoto, M.; Mizutani, K.; Sekizawa, Y. (Meiji Seika Kaisha, Ltd.)
来源:BE 875070; JP 1979125680
合成路线图解说明:

The condensation of 5-hydroxy-2-hydroxymethylpyridine (I) with 1,1,1-trifluoro-5-bromopentane (II) by means of KOH in hot DMF gives 5-(5,5,5 trifluoropentyloxy)-2-hydroxymethylpyridine (III), which is then oxidized with KMnO4 in butanol water.

参考文献No.41891
标题:5-Substituted picolinic acid derivatives and an anti-hypertensive composition containing the same
作者:Seikizawa, Y.; et al. (Meiji Seika Kaisha, Ltd.)
来源:US 4229448
合成路线图解说明:

The condensation of 5-hydroxy-2-hydroxymethylpyridine (I) with 1,1,1-trifluoro-5-bromopentane (II) by means of KOH in hot DMF gives 5-(5,5,5 trifluoropentyloxy)-2-hydroxymethylpyridine (III), which is then oxidized with KMnO4 in butanol water.

参考文献No.201843
标题:Trifluoropentoxypicolinic acid
作者:Casta馿r, J.; Prous, J.
来源:Drugs Fut 1985,10(7),573
合成路线图解说明:

The condensation of 5-hydroxy-2-hydroxymethylpyridine (I) with 1,1,1-trifluoro-5-bromopentane (II) by means of KOH in hot DMF gives 5-(5,5,5 trifluoropentyloxy)-2-hydroxymethylpyridine (III), which is then oxidized with KMnO4 in butanol water.

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