HIPDM-药物合成数据库

【药物名称】HIPDM

化学结构式(Chemical Structure):

参考文献No.	77474
标题:	HIPDM
作者:	Kung, H.F.; Hostyniak, P.J.
来源:	Drugs Fut 1985,10(9),742

合成路线图解说明: The 5-methylsalicylaldehyde (I) is prepared by a tin (IV) chloride-catalyzed formylation. Iodination of the aldehyde with ICl in glacial acetic acid gives good yield of 3-methyl-5-iodobenzylaldehyde (III). The iodinated salicylaldehyde is reductively aminated with N,N,N'-trimethylpropane-1,3-diamine and sodium borohydride to give N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamine (HIPDM) (III) in excellent yield.

参考文献No.	607666
标题:	Radioiodine-labeled N,N-dimethyl-N'-(2-hydroxy-3-a駅yl-5-iodobenzyl)-1,3.propanediamines for Brain Perfusion Imaging
作者:	Tramposch, K.M.; Kung, H.F.; Blau, M.
来源:	J Med Chem 1983,28(2),121-125

合成路线图解说明: The 5-methylsalicylaldehyde (I) is prepared by a tin (IV) chloride-catalyzed formylation. Iodination of the aldehyde with ICl in glacial acetic acid gives good yield of 3-methyl-5-iodobenzylaldehyde (III). The iodinated salicylaldehyde is reductively aminated with N,N,N'-trimethylpropane-1,3-diamine and sodium borohydride to give N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamine (HIPDM) (III) in excellent yield.