【药物名称】d-Fenfluramine hydrochloride, Dexfenfluramine hydrochloride, IP-001, S-5614, Isolipan, Redux, Adifax, Glypolix, Isomeride
化学结构式(Chemical Structure):
参考文献No.77482
标题:Dexfenfluramine Hydrochloride
作者:Nathan, C.
来源:Drugs Fut 1987,12(9),845
合成路线图解说明:

The (+) isomer of fenfluramine is obtained in the following way: The action of d-camphoric acid on (rac)-fenfluramine (I) forms the camphorate of (+)-fenfluramine (II). After purification of this salt by crystallization, sodium hydroxide in methylene chloride is added, forming (+)-fenfluramine (III) after removal of camphoric acid. Finally, the action of hydrogen chloride in methyl cyclohexane on (+)-fenfluramine produces the corresponding salt: (+)-fenfluramine hydrochloride.

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