REV-3164, RHC-3164-药物合成数据库

【药物名称】REV-3164, RHC-3164

化学结构式(Chemical Structure):

参考文献No.	46038
标题:	Triazaloquinoxalin-1,4-diones
作者:	Brown, R.E.; Georgiev, V.; Kropp, P.; Loev, B. (USV Pharmaceutical Corp.)
来源:	EP 0039920; JP 57004988; US 4400382

合成路线图解说明: The cyctization of 4-chloro-2-(propylamino)aniline (I) with oxalyl chloride (II) in hot o-dichlorobenzene gives 1-propyl-7-chloroquinoxaline-2,3-dione (III), which by reaction with SOCl2 in DMF is converted to 3,7-dichloro-1-propyl-1H-quinoxalin-2-one (IV). The condensation of (IV) with ethyl carbazate (V) in refluxing acetonitrile affords ethyl 3-(7-chloro-1-propyl-2-oxo-1H-quinoxalin-3-yl)carbazate (VI), which is finally cyclized by heating at 260 C.

参考文献No.	79486
标题:	RHC-3164
作者:	Chu, S.S.; Casta馿r, J.; Serradell, M.N.
来源:	Drugs Fut 1985,10(12),985

合成路线图解说明: The cyctization of 4-chloro-2-(propylamino)aniline (I) with oxalyl chloride (II) in hot o-dichlorobenzene gives 1-propyl-7-chloroquinoxaline-2,3-dione (III), which by reaction with SOCl2 in DMF is converted to 3,7-dichloro-1-propyl-1H-quinoxalin-2-one (IV). The condensation of (IV) with ethyl carbazate (V) in refluxing acetonitrile affords ethyl 3-(7-chloro-1-propyl-2-oxo-1H-quinoxalin-3-yl)carbazate (VI), which is finally cyclized by heating at 260 C.