Enciprazine, Wy-48624(diHCl), D-13112-药物合成数据库

【药物名称】Enciprazine, Wy-48624(diHCl), D-13112

化学结构式(Chemical Structure):

参考文献No.	79478
标题:	Enciprazine
作者:	Engel, J.; Jakovlev, V.; Kleemann, A.
来源:	Drugs Fut 1981,6(5),278

合成路线图解说明: By reaction of 1-(3-chloro-2-hydroxypropyl)-4-(2-methoxyphenyl)piperazine (III), obtained from 2-methoxyphenylpiperazine (I) and epichlorohydrine (II), with the sodium salt of 3,4,5-trimethoxyphenol (IV) in refluxing dioxane.

合成路线图解说明: By reaction of 3,4,5-trimethoxyphenoxyglycidylether (VI) [obtained by reaction of 3,4,5-trimethoxyphenol (V) with epichlorohydrine (II)] with 1-(2-methoxyphenyl)piperazine (I) in refluxing isopropanol.

参考文献No.	701346
标题:
作者:	Kleemann, A.
来源:	DE 2814168

合成路线图解说明: By reaction of 1-(3-chloro-2-hydroxypropyl)-4-(2-methoxyphenyl)piperazine (III), obtained from 2-methoxyphenylpiperazine (I) and epichlorohydrine (II), with the sodium salt of 3,4,5-trimethoxyphenol (IV) in refluxing dioxane.

合成路线图解说明: By reaction of 3,4,5-trimethoxyphenoxyglycidylether (VI) [obtained by reaction of 3,4,5-trimethoxyphenol (V) with epichlorohydrine (II)] with 1-(2-methoxyphenyl)piperazine (I) in refluxing isopropanol.