Etintidine hydrochloride, BL-5641A-药物合成数据库

【药物名称】Etintidine hydrochloride, BL-5641A

化学结构式(Chemical Structure):

参考文献No.	47470
标题:	Imidazolylmethylthioethyl alkynyl guanidines
作者:	Crenshaw, R.R.; Luke, G.M. (Bristol-Myers Squibb Co.)
来源:	US 4112234

合成路线图解说明: By condensation of N-cyano-N'-[2-[(5-methyl-4-imidazolyl)methylthio]ethyl]-S-methylisothiourea (I) with propargylamine (II) in refluxing acetonitrile.

合成路线图解说明: The reaction of propargylamine (II) with dimethyl cyanoiminodithiocarbonate (III) in refluxing acetonitrile gives N-cyano-N'-propargyl-S-methylisothiourea (IV), which is then condensed with 2-[(5-methyl-4-imidazolyl)methylthio]ethylamine (V) in refluxing methanol.

参考文献No.	79476
标题:	Etintidine hydrochloride
作者:	Serradell, M.N.; Blancafort, P.; Casta馿r, J.
来源:	Drugs Fut 1982,7(10),732

合成路线图解说明: By condensation of N-cyano-N'-[2-[(5-methyl-4-imidazolyl)methylthio]ethyl]-S-methylisothiourea (I) with propargylamine (II) in refluxing acetonitrile.

合成路线图解说明: The reaction of propargylamine (II) with dimethyl cyanoiminodithiocarbonate (III) in refluxing acetonitrile gives N-cyano-N'-propargyl-S-methylisothiourea (IV), which is then condensed with 2-[(5-methyl-4-imidazolyl)methylthio]ethylamine (V) in refluxing methanol.