Tianeptine sodium, S-1574, Stablon-药物合成数据库

【药物名称】Tianeptine sodium, S-1574, Stablon

化学结构式(Chemical Structure):

参考文献No.	79479
标题:	S-1574
作者:	Casta馿r, J.; Neuman, M.; Blancafort, P.; Serradell, M.N.
来源:	Drugs Fut 1979,4(7),522

合成路线图解说明: The condensation of 3,11-dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine S,S-dioxide (I) with ethyl 7-aminoheptanoate (II) in nitromethane gives ethyl 7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoate S,S-dioxide (III), which is then hydrolyzed with NaOH in refluxing ethanol.

参考文献No.	700980
标题:	Tricyclic compounds
作者:	Malen, C.; et al.
来源:	US 3758528

合成路线图解说明: The condensation of 3,11-dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine S,S-dioxide (I) with ethyl 7-aminoheptanoate (II) in nitromethane gives ethyl 7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoate S,S-dioxide (III), which is then hydrolyzed with NaOH in refluxing ethanol.