【药物名称】Talmetacin, PV-102, BA-7605-06
化学结构式(Chemical Structure):
参考文献No.701335
标题:
作者:
来源:AR 282717
合成路线图解说明:

This compound can be obtained in tvvo different ways: 1) The reaction of 3-bromophthalide (A) with 5-methoxy-2-methyl-1H-indole-3-acetic acid (I) previously salified with triethylamine in refluxing acetone gives (?-1,3-dihydro-3-oxo-1-isobenzofuranyl-5-methoxy-2-methyl-1H-indole-3-acetate (II). Compound (II) is salified with sodium hydride and then acylated with p-chlorobenzoyl chloride (B). 2) By condensation of the organic salt of 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid (III) with 3-bromophthalide (A).

参考文献No.701336
标题:
作者:Los, M.A.
来源:BE 0858897
合成路线图解说明:

This compound can be obtained in tvvo different ways: 1) The reaction of 3-bromophthalide (A) with 5-methoxy-2-methyl-1H-indole-3-acetic acid (I) previously salified with triethylamine in refluxing acetone gives (?-1,3-dihydro-3-oxo-1-isobenzofuranyl-5-methoxy-2-methyl-1H-indole-3-acetate (II). Compound (II) is salified with sodium hydride and then acylated with p-chlorobenzoyl chloride (B). 2) By condensation of the organic salt of 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid (III) with 3-bromophthalide (A).

参考文献No.800428
标题:Talmetacin
作者:Torriani, H.
来源:Drugs Fut 1982,7(11),825
合成路线图解说明:

This compound can be obtained in tvvo different ways: 1) The reaction of 3-bromophthalide (A) with 5-methoxy-2-methyl-1H-indole-3-acetic acid (I) previously salified with triethylamine in refluxing acetone gives (?-1,3-dihydro-3-oxo-1-isobenzofuranyl-5-methoxy-2-methyl-1H-indole-3-acetate (II). Compound (II) is salified with sodium hydride and then acylated with p-chlorobenzoyl chloride (B). 2) By condensation of the organic salt of 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid (III) with 3-bromophthalide (A).

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