Cinolazepam, OX-373, Gerodorm-药物合成数据库

【药物名称】Cinolazepam, OX-373, Gerodorm

化学结构式(Chemical Structure):

参考文献No.	46754
标题:	Novel 3-hydroxy-1,4-benzodiazepine-2-ones and process for the preparation thereof
作者:	Schlager, L.H. (Gerot Pharmazeutika GmbH)
来源:	AT 361492B; DE 2950235; ES 8103738; FR 2444672; US 4388313

合成路线图解说明: 7-Chloro-3-hydroxy-5-(2'-fluorophenyl)-1,3-(dihydro-2H-1,4-benzodiazepin-2-one (I) is mixed with acrylonitrile (II), and after dropwise addition of triethylbenzylammonium chloride (A) and benzyl trimethylammonium hydroxide (B), stirring is continued for 8 hours. The crude material was recrystallized from acetonitrile.

参考文献No.	154676
标题:	Cinolazepam
作者:	Koch, H.
来源:	Drugs Fut 1982,7(2),98

合成路线图解说明: 7-Chloro-3-hydroxy-5-(2'-fluorophenyl)-1,3-(dihydro-2H-1,4-benzodiazepin-2-one (I) is mixed with acrylonitrile (II), and after dropwise addition of triethylbenzylammonium chloride (A) and benzyl trimethylammonium hydroxide (B), stirring is continued for 8 hours. The crude material was recrystallized from acetonitrile.