Piketoprofen, Calmatel-药物合成数据库

【药物名称】Piketoprofen, Calmatel

化学结构式(Chemical Structure):

参考文献No.	41871
标题:	Amide derivs. of 3-benzoyl-phenylalkanoic acids
作者:	Vega Noverola, A.; Prieto Soto, J.; Spickett, R.G.W.
来源:	GB 1436502

合成路线图解说明: The reaction of 2-(3-benzoylphenyl)propionic acid (I) with SOCl2 or PCl3 gives the corresponding acyl chloride (II), which is then condensed with 4-methylpyridine-2-amine (III) by means of 4-methylpyridine in pyridine.

参考文献No.	41913
标题:	Procedimiento para la preparaci髇 de una amida de la 2-amino-4-metylpiridina
作者:	Vega, A.; Prieto, J.; Moragues, J. (Fordonal SL)
来源:	BE 0882711; ES 8102556; IT 1130573

合成路线图解说明: The reaction of 2-(3-benzoylphenyl)propionic acid (I) with SOCl2 or PCl3 gives the corresponding acyl chloride (II), which is then condensed with 4-methylpyridine-2-amine (III) by means of 4-methylpyridine in pyridine.