Cefotetan disodium, ICI-156834(free acid), YM-09330, Cefotan, Apatef, Yamatetan-药物合成数据库

【药物名称】Cefotetan disodium, ICI-156834(free acid), YM-09330, Cefotan, Apatef, Yamatetan

化学结构式(Chemical Structure):

参考文献No.	199347
标题:	Cefotetan
作者:	Blancafort, P.; Casta馿r, J.; Sweetman, A.J.; Serradell, M.N.
来源:	Drugs Fut 1981,6(10),609

合成路线图解说明: The condensation of 4-carboxy-3-hydroxy-5-mercaptoisothiazol (I) with 7beta-bromoacetamido-7alpha-methoxycephalosporanic acid (II) gives 7beta-(4-carboxy-3-hydroxyisothiazol-5-yl)thioacetamido-7alpha-methoxycephalosporanic acid (III), which by treatment with NaHCO3 in hot water is converted into 7beta-[4-(carbamoyl)(carboxy)methylene-1,3-dithietan-2-yl]carboxamido-7alpha-methoxycephalosporanic acid (IV). Finally, this compound is condensed with 5-mercapto-1-methyltetrazol (V) by means of Na2CO3 in water.

参考文献No.	700881
标题:	7alpha-Methoxy-7beta-(1,3-dithietane-2-carboxamido)cephalosporanic acid derivatives
作者:	Iwanami, M.; Maeda, T.; Nagano, Y.; Fujimoto, M.; Nagano, N.; Yamazaki, A.
来源:	BE 0867994; DE 2824559; FR 2405952; NL 7806208; US 4263432; US 4404373

合成路线图解说明: The condensation of 4-carboxy-3-hydroxy-5-mercaptoisothiazol (I) with 7beta-bromoacetamido-7alpha-methoxycephalosporanic acid (II) gives 7beta-(4-carboxy-3-hydroxyisothiazol-5-yl)thioacetamido-7alpha-methoxycephalosporanic acid (III), which by treatment with NaHCO3 in hot water is converted into 7beta-[4-(carbamoyl)(carboxy)methylene-1,3-dithietan-2-yl]carboxamido-7alpha-methoxycephalosporanic acid (IV). Finally, this compound is condensed with 5-mercapto-1-methyltetrazol (V) by means of Na2CO3 in water.