Tulobuterol hydrochloride, HN-078(patch), C-78, Hokunalin, Berachin-药物合成数据库

【药物名称】Tulobuterol hydrochloride, HN-078(patch), C-78, Hokunalin, Berachin

化学结构式(Chemical Structure):

参考文献No.	199356
标题:	C 78
作者:	Casta馿r, J.; Thorpe, P.
来源:	Drugs Fut 1976,1(5),217

合成路线图解说明: The oxidation of 2-chloroacetophenone (I) with SeO2 in dioxane-water gives 2-chlorophenylglyoxal (II), b.p. 87-90 C/1 mm, which is then reductocondensed with tert-butylamine (III) and NaSH4 in ethanol.

参考文献No.	701111
标题:	Verfahren zur Herstellung con Derivaten des Chlorbenzylalkohols
作者:	Kato, H.; Kurata, S.
来源:	BE 0788737; DE 2244737; ES 406646; FR 2154082; JP 48034848

合成路线图解说明: The oxidation of 2-chloroacetophenone (I) with SeO2 in dioxane-water gives 2-chlorophenylglyoxal (II), b.p. 87-90 C/1 mm, which is then reductocondensed with tert-butylamine (III) and NaSH4 in ethanol.