【药物名称】Sagamacin, Micronomicin sulfate, XK-62-2(free base), KW-1062(free base), Santemycin, Sagamicin
化学结构式(Chemical Structure):
参考文献No.701464
标题:
作者:Matsushima, H.; et al.
来源:JP 75126639
合成路线图解说明:

1) By methylation of gentamicin C1a (I) with methyl p-toluenesulfonate (A) in acetonitrile. 2) By methylation of gentamicin C1a (I) with methyl bromide (B) in methanol. 3) The reaction of gentamicin C1a (I) with CS2 in ethanol gives the 6'-N-dithiocarbamylgentamicin (II), C1a which is reduced with LiAlH4 in refluxing THF.

参考文献No.701465
标题:
作者:Matsushima, H.; et al.
来源:JP 75149647
合成路线图解说明:

4) The reaction of gentamicin C1a (I) with formaldehyde in ethanol gives 6'-N-methylenegentamicin C1a (III), which is then reduced with NaBH4, or with hot formic acid. 5) The reaction of gentamicin C1a (I) with ethyl chloroformate (C) by means of NaOH in dioxane yields ethyl 6'-carbamategentamicin C1a (IV), which is then reduced with LiAlH4 in THF.

参考文献No.701466
标题:
作者:Matsushima, H.; et al.
来源:JP 75149646
合成路线图解说明:

4) The reaction of gentamicin C1a (I) with formaldehyde in ethanol gives 6'-N-methylenegentamicin C1a (III), which is then reduced with NaBH4, or with hot formic acid. 5) The reaction of gentamicin C1a (I) with ethyl chloroformate (C) by means of NaOH in dioxane yields ethyl 6'-carbamategentamicin C1a (IV), which is then reduced with LiAlH4 in THF.

参考文献No.701467
标题:
作者:Matsushima, H.; et al.
来源:JP 75131949
合成路线图解说明:

4) The reaction of gentamicin C1a (I) with formaldehyde in ethanol gives 6'-N-methylenegentamicin C1a (III), which is then reduced with NaBH4, or with hot formic acid. 5) The reaction of gentamicin C1a (I) with ethyl chloroformate (C) by means of NaOH in dioxane yields ethyl 6'-carbamategentamicin C1a (IV), which is then reduced with LiAlH4 in THF.

参考文献No.701468
标题:
作者:Matsushima, H.; et al.
来源:JP 75123640
合成路线图解说明:

1) By methylation of gentamicin C1a (I) with methyl p-toluenesulfonate (A) in acetonitrile. 2) By methylation of gentamicin C1a (I) with methyl bromide (B) in methanol. 3) The reaction of gentamicin C1a (I) with CS2 in ethanol gives the 6'-N-dithiocarbamylgentamicin (II), C1a which is reduced with LiAlH4 in refluxing THF.

参考文献No.701469
标题:
作者:Matsushima, H.; et al.
来源:JP 75129531
合成路线图解说明:

1) By methylation of gentamicin C1a (I) with methyl p-toluenesulfonate (A) in acetonitrile. 2) By methylation of gentamicin C1a (I) with methyl bromide (B) in methanol. 3) The reaction of gentamicin C1a (I) with CS2 in ethanol gives the 6'-N-dithiocarbamylgentamicin (II), C1a which is reduced with LiAlH4 in refluxing THF.

参考文献No.800520
标题:Sagamicin
作者:Casta馿r, J.; Sweetman, A.J.; Serradell, M.N.; Blancafort, P.
来源:Drugs Fut 1979,4(5),360
合成路线图解说明:

1) By methylation of gentamicin C1a (I) with methyl p-toluenesulfonate (A) in acetonitrile. 2) By methylation of gentamicin C1a (I) with methyl bromide (B) in methanol. 3) The reaction of gentamicin C1a (I) with CS2 in ethanol gives the 6'-N-dithiocarbamylgentamicin (II), C1a which is reduced with LiAlH4 in refluxing THF.

合成路线图解说明:

4) The reaction of gentamicin C1a (I) with formaldehyde in ethanol gives 6'-N-methylenegentamicin C1a (III), which is then reduced with NaBH4, or with hot formic acid. 5) The reaction of gentamicin C1a (I) with ethyl chloroformate (C) by means of NaOH in dioxane yields ethyl 6'-carbamategentamicin C1a (IV), which is then reduced with LiAlH4 in THF.

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