Febuprol, K-10033, Valbil-药物合成数据库

【药物名称】Febuprol, K-10033, Valbil

化学结构式(Chemical Structure):

参考文献No.	201781
标题:	Febuprol
作者:	Janiak, P. St.
来源:	Drugs Fut 1978,3(3),191

合成路线图解说明: 1) By condensation of phenol (I) with 1-n-butoxy-2,3-epoxypropane (VII) in presence of potassium hydroxide. 2) By condensation of phenol (I) with 1-chloro-2,3-epoxypropane (II) followed either by addition of n-butanol (VI) in presence of a Lewis acid or in presence of a base (IV).

参考文献No.	701020
标题:	Procedimiento de fabricaci髇 de sustancias medicinalmente activas y m閠odo de preparaci髇 de medicamentos de acci髇 coler閠ica
作者:	Hoffmann, H.; et al.
来源:	ES 402799; FR 2134389; GB 1393451; US 3839587

合成路线图解说明: 1) By condensation of phenol (I) with 1-n-butoxy-2,3-epoxypropane (VII) in presence of potassium hydroxide. 2) By condensation of phenol (I) with 1-chloro-2,3-epoxypropane (II) followed either by addition of n-butanol (VI) in presence of a Lewis acid or in presence of a base (IV).