【药物名称】Sulcephalosporin, Cefsulodin sodium, SCE-129, CGP-7174/E, Abbott-46811, Tilmapor, Takesulin, Pseudomonil, Pseudocef, Monaspor
化学结构式(Chemical Structure):
参考文献No.201787
标题:Cefsulodin
作者:Blancafort, P.; Casta馿r, J.; Serradell, M.N.; Sweetman, A.J.
来源:Drugs Fut 1980,5(2),67
合成路线图解说明:

The reaction of 7-aminocephalosporanic acid (I) with alpha-sulfophenylacetyl chloride (II) by means of NaOH and NaHCO3 in ether gives 7-(alpha-sulfophenylacetamido)cephalosporanic acid (III), which is then condensed with isonicotinamide (IV) by means of KSCN and pyridine in water.

参考文献No.607985
标题:Semisynthetic beta-lactam antibiotics. 6. Sulfocephalosporins and their antipseudomonal activities
作者:Nomura, H.; Fugono, T.; Hitaka, T.; Minami, I.; Azuma, T.; Morimoto, S.; Masuda, T.
来源:J Med Chem 1974,17(12),1312-15
合成路线图解说明:

The reaction of 7-aminocephalosporanic acid (I) with alpha-sulfophenylacetyl chloride (II) by means of NaOH and NaHCO3 in ether gives 7-(alpha-sulfophenylacetamido)cephalosporanic acid (III), which is then condensed with isonicotinamide (IV) by means of KSCN and pyridine in water.

参考文献No.700902
标题:Cephalosporin compounds
作者:Morimoto, S.; et al.
来源:DE 2234280; ES 404745; FR 2146313; NL 7209811
合成路线图解说明:

The reaction of 7-aminocephalosporanic acid (I) with alpha-sulfophenylacetyl chloride (II) by means of NaOH and NaHCO3 in ether gives 7-(alpha-sulfophenylacetamido)cephalosporanic acid (III), which is then condensed with isonicotinamide (IV) by means of KSCN and pyridine in water.

参考文献No.800231
标题:Semisynthetic beta-lactams antibiotics. VII. New semisynthetic cephalosporins derived from alpha-sulfophenylacetic acid
作者:Nomura, H.; et al.
来源:Heterocycles 1974,2(1),67-72
合成路线图解说明:

The reaction of 7-aminocephalosporanic acid (I) with alpha-sulfophenylacetyl chloride (II) by means of NaOH and NaHCO3 in ether gives 7-(alpha-sulfophenylacetamido)cephalosporanic acid (III), which is then condensed with isonicotinamide (IV) by means of KSCN and pyridine in water.

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