Triflusal, UR-1501, Tecnosal, Disgren-药物合成数据库

【药物名称】Triflusal, UR-1501, Tecnosal, Disgren

化学结构式(Chemical Structure):

参考文献No.	199337
标题:	Triflusal
作者:	Mar韓, A.; Francia, E.; Garc韆 Rafanell, J.
来源:	Drugs Fut 1978,3(3),225

合成路线图解说明: Trifluoromethylphenol (I) is converted into 2-hydroxy-4-trifluoromethylbenzoic acid (II) by treatment with potassium carbonate and carbon dioxide under pressure (Kolbe-Schmitt reaction). (II) is then converted with a suitable acetylating agent in the 2-acetoxy-4-trifluoromethylbenzoic acid (III).

参考文献No.	701010
标题:	4-Trifluoromethylbenzoic acid derivatives as thromboembolic agents
作者:	Barra, E.F.; Mar韓, A.
来源:	DE 2641556; ES 459855; FR 2354335; GB 1588633; JP 52156831; US 4096252

合成路线图解说明: Trifluoromethylphenol (I) is converted into 2-hydroxy-4-trifluoromethylbenzoic acid (II) by treatment with potassium carbonate and carbon dioxide under pressure (Kolbe-Schmitt reaction). (II) is then converted with a suitable acetylating agent in the 2-acetoxy-4-trifluoromethylbenzoic acid (III).