Bromebrate sodium, NSC-104801, Cytembena-药物合成数据库

【药物名称】Bromebrate sodium, NSC-104801, Cytembena

化学结构式(Chemical Structure):

参考文献No.	199334
标题:	Cytembena
作者:	Casta馿r, J.; Hopkins, S.J.
来源:	Drugs Fut 1977,2(6),374

合成路线图解说明: The reaction of lambda-(4-methoxyphenyl)-alpha,beta-dibromocrotonolactone (I) with MgO in refluxing dioxane gives beta-(4-methoxy-benzoyl)-beta-bromoacrylic acid (II), which was then treated with sodium in ethanol.

参考文献No.	800273
标题:	Substanzen mit antineoplasticher wirksamkeit. V. Solvolyse einiger gamma-aryl-alpha,beta-dihalogen-delta(alpha,beta)-crotonlactone
作者:	Semonsk? M.; et al.
来源:	Coll Czech Chem Commun 1963,28377

合成路线图解说明: The reaction of lambda-(4-methoxyphenyl)-alpha,beta-dibromocrotonolactone (I) with MgO in refluxing dioxane gives beta-(4-methoxy-benzoyl)-beta-bromoacrylic acid (II), which was then treated with sodium in ethanol.