【药物名称】Clonazepam, Ro-5-4023, Klonopin Wafers, Rivotril, Klonopin, Clonopin
化学结构式(Chemical Structure):
参考文献No.562902
标题:Development of a commercially viable clonazepam process
作者:McDonough, J.A.; et al.
来源:Org Process Res Dev 1997,1(4),268
合成路线图解说明:

A new commercially viable process to clonazepam has been reported. Chloroacetamide intermediate (I) was activated as the corresponding iodide (II) by Finkelstein exchange reaction with KI in acetone. Subsequent displacement by ammonia in EtOAc as the solvent afforded the glycine amide (III). Finally, cyclization of (III) in the presence of ethanolic pyridine gave rise to the title benzodiazepinone.

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