【药物名称】Zotepine, FR-1314, Engramon, Zoleptil, Nipolept, Lodopin
化学结构式(Chemical Structure):
参考文献No.47017
标题:Tricyclic enol ether compounds
作者:Umio, S.; et al. (Fujisawa Pharmaceutical Co., Ltd.)
来源:DE 1907670; FR 2002064; GB 1247067; NL 6902489; US 3704245
合成路线图解说明:

Compound can be prepared in two different ways: 1) By condensation of 8-chlorodibenzo[b,f]thiepin-10(11H)-one (I) with 2-dimethylaminoethyl chloride (II) by means of NaH in benzene - DMF at 60 C. 2) By condensation of 8-chloro-10-(2-chloroethoxy)dibenzo[b,f]thiepin (III) with dimethylamine.

参考文献No.313536
标题:Zotepine
作者:Blancafort, P.; Serradell, M.N.; Hillier, K.; Casta馿r, J.
来源:Drugs Fut 1979,4(10),758
合成路线图解说明:

Compound can be prepared in two different ways: 1) By condensation of 8-chlorodibenzo[b,f]thiepin-10(11H)-one (I) with 2-dimethylaminoethyl chloride (II) by means of NaH in benzene - DMF at 60 C. 2) By condensation of 8-chloro-10-(2-chloroethoxy)dibenzo[b,f]thiepin (III) with dimethylamine.

参考文献No.700979
标题:
作者:Umio, S.; Ueta, I.
来源:JP 7235439
合成路线图解说明:

Compound can be prepared in two different ways: 1) By condensation of 8-chlorodibenzo[b,f]thiepin-10(11H)-one (I) with 2-dimethylaminoethyl chloride (II) by means of NaH in benzene - DMF at 60 C. 2) By condensation of 8-chloro-10-(2-chloroethoxy)dibenzo[b,f]thiepin (III) with dimethylamine.

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