Phentolamine mesilate, Z-Max, Vasofem, Vasomax, Regitin-药物合成数据库

【药物名称】Phentolamine mesilate, Z-Max, Vasofem, Vasomax, Regitin

化学结构式(Chemical Structure):

参考文献No.	36772
标题:	2-(N,N-Diphenyl-aminomethyl)imidazoles
作者:	Miescher, K.; Marxer, A.; Urech, E. (Novartis Corp.)
来源:	US 2503059

合成路线图解说明: The condensation of N-(3-hydroxyphenyl)-N-(4-methylphenyl)amine (I) with 2-(chloromethyl)-4,5-dihydro-1H-imidazole (II) by heating at 150-60 C without solvent or in o-dichlorobenzene gives phentolamine as hydrochloride salt (III), which is treated with ammonia to obtain the free base, and finally salified with methanesulfonic acid in ethanol.

参考文献No.	525199
标题:	2-Aminoalkyl-imidazoline
作者:	Miescher, K.; Marxer, A.; Urech, E.
来源:	Helv Chim Acta 1950,33(5),1386-407

合成路线图解说明: The condensation of N-(3-hydroxyphenyl)-N-(4-methylphenyl)amine (I) with 2-(chloromethyl)-4,5-dihydro-1H-imidazole (II) by heating at 150-60 C without solvent or in o-dichlorobenzene gives phentolamine as hydrochloride salt (III), which is treated with ammonia to obtain the free base, and finally salified with methanesulfonic acid in ethanol.