Lofepramine hydrochloride, Gamanil, Gamonil-药物合成数据库

【药物名称】Lofepramine hydrochloride, Gamanil, Gamonil

化学结构式(Chemical Structure):

参考文献No.	313546
标题:	Lofepramine
作者:	Casta馿r, J.; Arrigoni-Martelli, E.
来源:	Drugs Fut 1976,1(3),129

合成路线图解说明: By condensation of N-methyl-3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propylamine (desipramine) (I) with 4-chlorophenacyl chloride (II) by means of NaHCO3 in benzene-water.

参考文献No.	604469
标题:	Chemistry and pharmacology of a new potential antidepressant
作者:	Eriksoo, E.; Rohte, O.
来源:	Arzneim-Forsch Drug Res 1970,20(10),1561

合成路线图解说明: By condensation of N-methyl-3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propylamine (desipramine) (I) with 4-chlorophenacyl chloride (II) by means of NaHCO3 in benzene-water.