【药物名称】Oxitropium bromide, BA-253, Oxivent
化学结构式(Chemical Structure):
参考文献No.326721
标题:Oxitropium bromide
作者:Dharma, A.P.
来源:Drugs Fut 1979,4(2),117
合成路线图解说明:

Compound can be prepared in three steps starting from (-)-scopalamine (hyoscine) (I) by demethylation of (-)-scopolamine with phosgene or potassium permanganate, by alkylation of the resulting (-)-norscopolamine (II) with ethylbromide (A) by means of sodium carbonate, and by quaternization of the resulting (-)-N-ethyl-norscopolamine (III) with methylbromide yielding Ba-253-BR.

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