【药物名称】Penbutolol sulfate, Hoe-893d, Hoe-39893d, Levatol, Betapressin
化学结构式(Chemical Structure):
参考文献No.701530
标题:
作者:Ruschig, H.; et al.
来源:ZA 6807915
合成路线图解说明:

The reaction of 2-cyclopentylphenol (I) with epichlorhydrin (II) in a basic medium yields 1,2-epoxy-3-(2'-cyclopentylphenoxy)propane (III), which is the condensed with tert-butylamine (IV) in hot ethanol.

参考文献No.800741
标题:Penbutolol
作者:Casta馿r, J.; Weetman, D.F.
来源:Drugs Fut 1976,1(10),494
合成路线图解说明:

The reaction of 2-cyclopentylphenol (I) with epichlorhydrin (II) in a basic medium yields 1,2-epoxy-3-(2'-cyclopentylphenoxy)propane (III), which is the condensed with tert-butylamine (IV) in hot ethanol.

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