Ranitidine hydrochloride, AH-19065, Quantor, Toriol, Tanidina, Azantac, Zantic, Zantac-药物合成数据库

【药物名称】Ranitidine hydrochloride, AH-19065, Quantor, Toriol, Tanidina, Azantac, Zantic, Zantac

化学结构式(Chemical Structure):

参考文献No.	345186
标题:	Ranitidine
作者:	Serradell, M.N.; Blancafort, P.; Casta馿r, J.; Hillier, K.
来源:	Drugs Fut 1979,4(9),663

合成路线图解说明: The reaction of 5-dimethylaminomethyl-2-furanylmethanol (I) with 2-mercaptoethylamine (II) by means of aqueous HCl gives 2-[[(5-dimethylamino-methyl-2-furanyl)methylthio]ethaneamine (III), which is then condensed with N-methyl-1-methylthio-2-nitrotheneamine (IV) by heating at 120 C. Compound (IV) is obtained by reaction of 1,1-bis(methylthio)-2-nitroethene (V) with methylamine in refluxing ethanol.

参考文献No.	900141
标题:	Aminoalkyl furan derivatives.
作者:	Price, B.J.; Bradshaw, J.; Clitherow, J.W. (Allen & Hansburys Ltd.)
来源:	DE 2734070; FR 2360587; US 4128658

合成路线图解说明: The reaction of 5-dimethylaminomethyl-2-furanylmethanol (I) with 2-mercaptoethylamine (II) by means of aqueous HCl gives 2-[[(5-dimethylamino-methyl-2-furanyl)methylthio]ethaneamine (III), which is then condensed with N-methyl-1-methylthio-2-nitrotheneamine (IV) by heating at 120 C. Compound (IV) is obtained by reaction of 1,1-bis(methylthio)-2-nitroethene (V) with methylamine in refluxing ethanol.