Amcinonide, CL-34699-药物合成数据库

【药物名称】Amcinonide, CL-34699

化学结构式(Chemical Structure):

参考文献No.	47596
标题:	Administration of 16alpha,17alpha-cyclopentylidenedioxy-9alpha-fluoro-11beta,21-dihydroxy-1,4-pregnadiene-3,20-dione-21-acetate
作者:	Sieger, G.M.; Krieger, C. (American Cyanamid Co.)
来源:	DE 2437847; FR 2240738; GB 1442925; US 4158055

合成路线图解说明: 9alpha,fluoro-11beta16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione (I) is ketalized by reaction with cyclopentanone (II) by means of perchloric acid yielding the ketal (III), which is then acetylated by reaction with acetic anhydride in pyridine.

参考文献No.	800610
标题:	Amcinodine
作者:	Hillier, K.; Casta馿r, J.
来源:	Drugs Fut 1978,3(5),337

合成路线图解说明: 9alpha,fluoro-11beta16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione (I) is ketalized by reaction with cyclopentanone (II) by means of perchloric acid yielding the ketal (III), which is then acetylated by reaction with acetic anhydride in pyridine.